Presentation of the École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris - PSL)
ESPCI Paris – PSL (École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris) is a generalist engineering school that has been training innovative, adaptable, and creative engineers since 1882. These engineers are equipped with a strong theoretical and experimental foundation and are aware of societal challenges.
The school is part of a research center internationally recognized for its work in physics, chemistry, and biology, producing 500 publications annually. It is known for its ability to transform fundamental research knowledge into breakthrough innovations (two patents per month, three start-ups per year).
Awarded six Nobel Prizes, ESPCI hosts 400 engineering students, 530 researchers (including 250 PhD students and 100 postdoctoral researchers) across 10 joint research units, and about 100 staff members supporting research and education.
Since its founding, ESPCI has consistently mobilized its strengths and expertise to address major societal issues and has championed the importance of science in the service of society. Environmental sustainability, solidarity, health, access to, and openness to knowledge are key concerns that ESPCI is committed to addressing daily while actively contributing to their advancement. ESPCI advocates for equal opportunities and promotes social diversity. It encourages and values student engagement, especially in associative work.
Our institution is part of Université Paris Sciences & Lettres, ranked first globally among young universities by Times Higher Education, and is also in the top 50 of the world’s best universities (Shanghai, Times Higher Education, QS, CWUR).
ESPCI is engaged in a large-scale renovation project of its Paris campus, which will make it one of the most modern scientific sites in Paris.
Position affiliation
The postdoctoral researcher will be affiliated with the Laboratory of Biological Mass Spectrometry and Proteomics at ESPCI Paris (SMBP, led by Joelle Vinh), under the supervision of Giovanni Chiappetta. The project is in collaboration with Agnes Delaunay-Moisan’s group at CEA Saclay.
Missions et responsibilities
Presentation of the project:
The ERXCUE project, funded by the ANR, aims to study how cells adapt—or fail to adapt—to endoplasmic reticulum (ER) stress, with a focus on the remodeling of thiol-redox metabolism. The goal is to identify the redox processes that influence the cellular decision between survival and apoptosis during the unfolded protein response (UPR). By combining unbiased -omics approaches with targeted studies at the subcellular proteomic level, the postdoctoral researcher will explore how redox activities contribute to the regulation of the UPR. The project is part of a collaboration with Agnes Delaunay-Moisan’s group at CEA Saclay.
Responsibilities:
- Proteomics and Redoxomics Analysis:
- Design and conduct mass spectrometry experiments (LC-MS/MS) to identify and quantify cysteine redox post-translational modifications in proteins involved in the UPR.
- Focus on thiol modifications and redox-active proteins.
- Data Integration:
- Integrate redox proteomics data with transcriptomics data to create a comprehensive map of redox pathways regulated by the UPR.
- Use bioinformatics tools to correlate proteomic data with cellular redox states and UPR transitions.
- Experimental Design:
- Develop and optimize methods for subcellular fractionation and redoxomics targeting specific organelles, particularly the endoplasmic reticulum (ER).
- Implement innovative workflows to map ER-specific redox modifications and redox activity under UPR stress conditions.
- Collaborative Research:
- Work closely with redox biology and metabolomics teams to understand how changes in thiol-redox metabolism and other pathways affect cellular responses to ER stress.
- Study metabolic remodeling under UPR and its impact on the proteome.
Profile
Desired knowledge and skills:
- Principles and experience in proteomics analysis
- Handling quantitative proteomics data
- Human cell culture
- Knowledge of R programming language (preferred, not mandatory)
Degree:
PhD in Biochemistry, Analytical Chemistry, or Biology
Preferred experience:
Early-career researcher (1st postdoc)
Position available from:
January 2025 for 18 months
Contact
Applications (CV, cover letter) should be submitted by email to giovanni.chiappetta@espci.fr
Address
10, Rue Vauquelin 75005 Paris
Métro 7 (Place Monge/Censier Daubenton) - RER B (Luxembourg) - Bus 21, 27 & 47
